In-depth study of the human histocompatibility polymorphisms will include genetic inheritance, alleles, typing methodologies, and matching requirements for solid organ and tissue transplantation. The human leukocyte antigen (HLA or MHC) system and its role in transplant rejection will be the major focus, however minor histocompatibility systems will also be examined.

Course content includes immunological, biochemical and genetic concepts and molecular biology related to the clinical process of transplantation. Cellular and molecular mechanisms will be an intense focus of this course. Solid organ and tissues transplantation, the need for donor organs and tissues, compatibility requirements for successful transplantation of each type of organ and tissue, immunosuppressive therapy, and research opportunities that may impact successful transplantation and tissue availability will be examined.

This course focuses on principles, applications and quality assurance of flow cytometry in research and clinical use in hematology and transplantation. Emphasis is placed on the biological and physical principles underlying flow cytometry, specimen processing, operation and specific application in the identification of various hematopoietic and other cells.

Normal and abnormal hemopoiesis is examined. Special emphasis is placed on understanding the relationship of hemopoiesis to hemoproliferative and immunologic disease; transplantation science, and medical applications.

This course will review current knowledge and hypotheses regarding both hypo and hyper coagulable states, drug induced disorders of hemostasis, treatment regimes, and the present state of the art in laboratory testing for high-risk individuals.

Advanced review of inherited and acquired disorders of erythrocyte production, destruction and loss including the hemoglobinopathies. The course will address the pathophysiology, laboratory testing and treatment of each disorder.

Research, design, protocol development and production of thesis are included. Grade will be reported following evaluation of written product by the thesis committee.

Half-time to full-time work on dissertation. May be repeated to a maximum of six semesters.

Residency credit for dissertation research after the qualifying examination. Students may register for this course in the semester of the qualifying examination. A minimum of two semesters are required as well as continuous enrollment (Fall and Spring) until the dissertation is completed and defended.

The goal of this course is to ensure that the student understands and can apply research methods to identifying a research problem, developing a proposal, conducting an investigation, and preparing a journal-quality research paper. Students will work closely with a clinical sciences researcher to develop these research skills. The course requirements and format will vary depending upon the student's prior experience.