Students must complete the checklist procedures while working under supervision. All ART procedures will be performed under supervision using appropriate models for practice. Procedures will include, in vitro fertilization and related procedures, micromanipulations including intracytoplasmic sperm injection, assisted hatching and preimplantation genetic diagnosis and cryopreservation of oocytes embryos.

Students in the RLS seminar will critique research papers in the field, will develop and present PowerPoint presentations on subjects covering andrology, ART, cryopreservation of human reproductive tissue, management issues in the reproductive laboratory, and policy, ethical and legal issues in ART. May be repeated for total of two credits.

Research projects for students in Reproductive Laboratory Science. Students will complete web- based modules, "The Scientific Method and the Art of Research" prior to project initiation. Projects should be related to the student'srea in individual interest and should address an area in reproductive laboratory science. Projects shouldh be under the supervision of a faculty member with expertise in the project area.

In-depth study of the human histocompatibility polymorphisms will include genetic inheritance, alleles, typing methodologies, and matching requirements for solid organ and tissue transplantation. The human leukocyte antigen (HLA or MHC) system and its role in transplant rejection will be the major focus, however minor histocompatibility systems will also be examined.

Course content includes immunological, biochemical and genetic concepts and molecular biology related to the clinical process of transplantation. Cellular and molecular mechanisms will be an intense focus of this course. Solid organ and tissues transplantation, the need for donor organs and tissues, compatibility requirements for successful transplantation of each type of organ and tissue, immunosuppressive therapy, and research opportunities that may impact successful transplantation and tissue availability will be examined.

This course focuses on principles, applications and quality assurance of flow cytometry in research and clinical use in hematology and transplantation. Emphasis is placed on the biological and physical principles underlying flow cytometry, specimen processing, operation and specific application in the identification of various hematopoietic and other cells.

Normal and abnormal hemopoiesis is examined. Special emphasis is placed on understanding the relationship of hemopoiesis to hemoproliferative and immunologic disease; transplantation science, and medical applications.

This course will review current knowledge and hypotheses regarding both hypo and hyper coagulable states, drug induced disorders of hemostasis, treatment regimes, and the present state of the art in laboratory testing for high-risk individuals.

Advanced review of inherited and acquired disorders of erythrocyte production, destruction and loss including the hemoglobinopathies. The course will address the pathophysiology, laboratory testing and treatment of each disorder.

Research, design, protocol development and production of thesis are included. Grade will be reported following evaluation of written product by the thesis committee.