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Biology alum's research could have eye-opening implications for NICU – his journey started here.

By Francis Von Mann

LEXINGTON, Ky. (Oct. 8, 2025) – In the Jacobs Science Building, a mural sprawls across a whiteboard. On one side, a magnified cell with swirling, intricate layers. On the other, Charles Darwin circled by Galápagos finches and double helixes. It is equal parts science and art, memorialized with a signature in the corner: Shane D’Souza, Class of 2018.

 

Biology alum's research could have eye-opening implications for NICU; his journey started here.

By Francis Von Mann

LEXINGTON, Ky. (Oct. 8, 2025) – In the Don & Cathy Jacobs Science Building, a mural sprawls across a whiteboard. On one side, a magnified cell with swirling, intricate layers. On the other, Charles Darwin circled by Galápagos finches and double helixes. It is equal parts science and art, memorialized with a signature in the corner: Shane D’Souza, Class of 2018.

Physics & Astronomy Colloquium

Dr. Brent Seales, University of Kentucky

Title: On Perseverance: Virtually Unwrapping the Herculaneum Scrolls

Abstract: This talk tells the story of virtual unwrapping, conceived during the rise of digital libraries, computer vision and large-scale computing, and now realized on some of the most difficult and iconic material in the world -- the Herculaneum Scrolls -- as a result of the recent phenomena of big data and machine learning. 

Virtual unwrapping is a noninvasive restoration pathway for damaged written material, allowing texts to be read from objects that are too damaged even to be opened. The Herculaneum papyrus scrolls, buried and carbonized by the eruption of Mount Vesuvius in 79 CE and then excavated in the 18th century, are original, classical texts from the shelves of the only library to have survived from antiquity. The 250-year history of science and technology applied to the challenge of opening and then reading them has created a fragmentary, damaged window into their literary and philosophical secrets. 

In 1999, with more than 400 scrolls still unopened, methods for physical unwrapping were permanently halted. The intact scrolls present an enigmatic challenge: preserved by the fury of Vesuvius, yet still lost. Using a noninvasive imaging approach, we have now shown how to recover their texts, rendering them "unlost." The path we have forged uses high energy physics, artificial intelligence and the collective power of a global scientific community inspired by prizes, collaborative generosity and the common goal of shared glory: reading original classical texts for the first time in 2,000 years.

Date:
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Location:
CP 153
Event Series:
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