Immunotherapy, the application of immunologic principles to the clinic, often called "Bench to Bedside", has led to significant objective clinical responses and prolonged time to tumor progression or recurrence in a subset of cancer patients. The current class will discuss basic immunologic principles and show how they apply to the tumor setting. In addition, the class will demonstrate how immunologic mechanisms can be exploited in the treatment of cancer. The semester will be divided into three stages including: 1.

Biology of cancer will be discussed at the molecular, cellular and organismic level. Emphasis will be placed on cellular signaling, apostosis and cell cycle unique to cancer cells, which affects tumor cell behavior and its interactions with the host immune system. The biology of hematopoitic cells will also be included. Clinicians active in treatment and research of various types of cancer will be invited to participate in the lectures.

MI 704 is targeted to pre-qualifying second-year graduate students pursuing a PhD, but may also be of value for post-qualifying graduate students and postdoctoral trainees. The primary objective is to help students improve their writing and critical thinking skills, structured around the development of an NIH National Research Service Award (NRSA) F31 Individual Fellowship. Students will become familiar with the NIH structure and resources, the different sections of an NRSA grant application, and the process of grant submission at UK.

This course will deal with controversial and evolving areas of immunology. Lectures in a given topic will be accompanied by student discussion of contemporary literture.

Mechanisms of Microbial Pathogenesis is designed to cover major pathogenic mechanisms of bacteria, protozoa, fungi and viruses. Since it is impossible to include every possible pathogen, we instead focus on selected pathogens that illustrate particular lifestyles and pathogenic strategies. Emphasis is given to covering host mechanisms that combat the different weapons and lifestyles of the disease causing microbes.

Half-time to full-time work on thesis. May be repeated to a maximum of six semesters.

May be repeated to a maximum of six semesters.

Residency credit for dissertation research after the qualifying examination. Students may register for this course in the semester of the qualifying examination. A minimum of two semesters are required as well as continuous enrollment (Fall and Spring) until the dissertation is completed and defended.

Residency credit for dissertation research after the qualifying examination. Students may register for this course in the semester of the qualifying examination. A minimum of two semesters are required as well as continuous enrollment (Fall and Spring) until the dissertation is completed and defended.

Residency credit for dissertation research after the qualifying examination. Students may register for this course in the semester of the qualifying examination. A minimum of two semesters are required as well as continuous enrollment (Fall and Spring) until the dissertation is completed and defended.