Introduction to medicinal chemistry will be explored through rational biochemical and physical organic chemical approaches to drug design, action and development. Structural features, physical properties, mechanism of action and metabolism of drug like molecules, forces that govern interaction of drug-like molecules with their targets, enzyme mechanisms and inhibition and xenobiotic metabolism will be illustrated with specific examples showing how drugs function at the molecular level.

Half-time to full-time work on thesis. May be repeated to a maximum of six semesters.

Residency credit for master's thesis.

Cooperative workshop offered only as an optional supplement to certain biology lecture courses. Offered only on a pass/fail basis.

Cooperative workshop offered only as an optional supplement to certain biology lecture courses. Offered only on a pass/fail basis.

Comparative study of the anatomy of vertebrates with emphasis on evolutionary change, adaptive and functional significance of structural organization and basic concepts of the comparative approach. Laboratory studies on representative vertebrates involving dissections, models, and demonstrations. Lecture, three hours; laboratory, four hours per week.

An overview of the physiography, geology, soils, hydrology, climate (paleo and recent), vegetation relationships), archaeobotany, and agriculture of Kentucky. Lecture, two hours; laboratory, two hours per week.

Selected topics in biology of special interest to teachers such as biological research experiences related to pharmacological assays, collecting behavioral data, compilation and statistically analysis of data. When the course is offered, a specific title with specific credits, the number of hours in lecture-discussion, will be given. Lecture/ discussion, two-four hours; laboratory, zero-four hours. May be repeated to a maximum of 12 credit hours.

This course is designed to provide students with a broad understanding of vertebrate endocrinology. Course topics will include the various classes of hormones, sources and synthesis of hormones, receptors and target tissues, mechanisms of action and regulation, and methods used in endocrinology and behavioral endocrinology. Details of classical endocrine systems will be explored. The last third of the course will focus on neuroendocrinology and how hormones influence the development and activation of behavior in humans and animal models.

Comparative and Functional Neuroanatomy explores the cellular bases for sensory, integrative and motor neuroscience from an evolutionary perspective, delineating common features of all nervous systems ranging from cnidarian nerve nets to ventral nerve cords of most invertebrates to the chordate/vertebrate central nervous systems. Discovery of the common features of nervous structure in model system organisms with the human brain will provide students a perspective on the value of model systems for future study.