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Hydrogenation and Hydrogenolysis of Furan Derivatives Using Electrophillic Ruthenium(II) Catalysts

Anitha Gowda of the UK Chemistry Department will be presenting a seminar entitled Hydrogenation and Hydrogenolysis of Furan Derivatives Using Electrophillic Ruthenium(II) Catalysts.

Faculty Advisor: Dr. Folami Ladipo

Date:
-
Location:
CP-137

Developing Green Technology for the Synthesis of Value Added Chemicals and Biologically Active Compounds

Dr. Neeraj Gupta of the UK Chemistry Department will be presenting a seminar entitled Developing Green Technology for the Synthesis of Value Added Chemicals and Biologically Active Compounds.

Refreshments will be served at 3:30pm.

All students welcome!

Faculty Supervisor: Dr. Folami Ladipo

Date:
-
Location:
CP-137
Event Series:

Chemistry Department Faculty Poster Session

 

This is an opportunity for the department's graduate students, as well as all other interested persons, to discover the research taking place in the Chemistry Department at the University of Kentucky. First-year graduate students are strongly encouraged to attend with their blue sheets, to get signatures from potential research mentors.

Date:
-
Location:
CP-137

The Disordered Regulation of Calcineurin

Dr. Trevor Creamer of the University of Kentucky's Molecular and Cellular Biochemistry Department will be presenting a seminar entitled, The Disordered Regulation of Calcineurin.

Abstract: Calcineurin (CaN) is a highly regulated Ser/Thr protein phosphatase that plays critical roles in learning and memory, cardiac development and function, and immune system activation. Alterations in CaN regulation contribute to multiple disease states such as Down syndrome, cardiac hypertrophy, Alzheimer’s disease, and autoimmune disease. Despite its importance, CaN regulation is not well understood at the molecular level. Full CaN activation requires binding of calcium-loaded calmodulin (CaM), however little is known about how CaM binding leads to CaN activation. I will present evidence that the 95 residue CaN regulatory domain, where the CaM binding region is located, is disordered. The binding of CaM to CaN results in the regulatory domain folding. Folding of this regulatory domain in turn causes an autoinhibitory domain to be ejected from CaN’s active site. It is this binding-induced disorder-to-order transition that is responsible for the activation of CaN by CaM.

 

Facutly Host: Dr. Jason DeRouchey

Date:
-
Location:
CP-137
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