Applications-based statistical and analytical software is used to demonstrate Continuing Quality Improvement (CQI) adherence to Federal regulation, NCCLS/IFCC protocols, and other accrediting agency requirements. Special emphasis is on defining and controlling unstable error through a statistical modeling approach. Documentation structures for quality operations policy; and processes, procedures and implementation of a quality system are examined with special attention to assuring quality of point- of-care testing. Detailed computerized study of method comparison includes receiver operator charting (ROC). Computerized diagnostic screening programs are used to evaluate prevalence, sensitivity, specificity, and predictive values. Utilization of management systems to track expenses, budget/inventory management, employee scheduling, productivity evaluations, process improvement and restructuring are demonstrated. Computerized performance management systems and innovations in compliance strategies are featured. Student evaluation will be based on examinations, projects, and papers.