This course is designed to provide the student with an advanced understanding of pain neurophysiology and pain pathophysiology. This course provides the student with advanced insights to chronic pain mechanism that result from central neuroplasticity. Specifically, the etiologic mechanisms of orofacial pain conditions will be discussed in detail, such as trigeminal neuralgia, persistent neuropathic pain and neuritis. The mechanisms of many primary headaches, such a migraine, trigeminal autonomic cephalgia and tension headache will also be discussed.