A study of human disease processes and rational pharmacotherapeutics relating to the autonomic, central and peripheral nervous system including a discussion of the factors influencing the development of substance dependence and the strategies for risk reduction. Emphasis is placed on the principles of pathophysiology, pharmacology, toxicology and therapeutics, the incorporation of these principles in the clinical application of modern drug therapy, and how these principles can be utilized in pharmacy practice. Variable mixture of lecture, group discussion and independent study.