This course enables student dentists to understand the basic principles of human physiology, especially as it relates to the practice of dentistry. The introduction of the course presents the basic physiology of cells, conducting and contracting tissues, lining and secretory tissues, and other special tissues. The course focuses on the major physiological systems and presents them at the system, cellular, and molecular levels; and emphasizes those aspects particularly relevant to dentistry - dentin sensitivity, dental and pulpal pain, muscle dysfunction, ischemic and, hypertensive heart disease, oral manifestations of endocrine abnormalities, temperature regulation, calcium-phosphate homeostasis, and the dental mineralized tissues. Upon successful completion of the course, student dentists will be able to rationally and scientifically apply basic cell, tissue, organ, and organ system function to clinical decision-making. Lectures with assigned reading: 68 hours.