The objective of the course will be to provide a general overview of the current state of knowledge concerning the pathophysiology and therapeutic approaches to central nervous system injury. The course will provide a strong working background concerning the issues, techniques and frontiers of neurotrauma therapeutic discovery research aimed at reducing acute post-traumatic neurodegeneration in the injured brain or spinal cord or enabling regeneration and repair. This course is a graduate level course intended for students who are in their second or subsequent years of graduate study and who are pursuing research training in neurotrauma research. No special prerequisites, othr than graudate standing are necessary. However, a background in neuroanatomy and neurophysiology is highly recommended.