This 12-month course is designed to provide the student with an advanced understanding of pain neurophysiology and pain pathophysiology. This course provides the student with advanced insights to chronic pain mechanism that result from central neuroplasticity. Specifically, the etiologic mechanisms of orofacial pain conditions will be discussed in detail, such as trigeminal neuralgia, persistent neuropathic pain and neuritis. The mechanisms of many primary headaches, such a migraine, trigeminal autonomic cephalgia and tension headache will also be discussed along with the effects of pharmacological and non- pharmacological treatment modalities. The student learns the orofacial pain dentist's role in the management of these complex orofacial pain disorders and how to interact with other appropriate healthcare providers.