Human immunology with an emphasis on experimental methods, signal transduction, cell-cell interactions, cytokine production and activity, cell marker expression during normal cell development, pathogenic expression of cell markers and their detection, immunotherapy, vaccine production and acquired immunity. Analysis of immunologic systems mediating the response to allogenic foreign molecules such as transplanted tissues and organs will be emphasized. Contemporary issues and trends in immunology, with an emphasis on malignancy and immunodeficiencies, will be examined.