This course covers the fundamental concepts involved in understanding and engineering a closed- loop, sensing, reasoning, and actuating agent. Biological models of sensing and actuation will be discussed and related to modern artificial counterparts. The course consists of three major topic areas: vision, brain, and robotics. It will introduce students to the issues in computer and biological vision, to models of belief representation and modification, architectures for percept processing and reasoning, machine learning for vision, neural networks, path planning, intelligent localization based on visual cues, and to forward and inverse kinematics, intelligent grasping, and the integration of perception and action.