This course provides students with the understanding of advanced issues in the design, analysis, and interpretation of epidemiologic studies. The course text and associated readings will focus on study designs and the methodologic approaches to addressing bias, confounding, and error in the design of population-based health research. The development of a systematic approach for evaluating evidence from epidemiologic studies as it relates to demonstrating causality will be emphasized. Focusing on study design, measures of associations, confounding, interaction, sources of bias and error, the student will gain an understanding of epidemiology and its role in the medical and public health sciences.