Using a One Health Systems lens, the course content will demonstrate how human, animal, plant, environmental, and ecosystem health are interconnected. The field of One Health is recognized by the Centers for Disease Control as an important approach to understanding existing and emerging disease, as well as how disruptions in environmental or animal health can directly impact the economic, social, and cultural aspects of human health. This course is divided into three modules. The first emphasizes approaches to the complexity of One Health Systems including upstream drivers of disease potential. The second module will focus on macro-level relationships in One Health practice. The final module will address contemporary topics affecting health. This course is a blended experience of recorded instructor lectures, guest speakers, recordings of conference proceedings, independent reading of articles, and case studies to explain the constructs of One Health Systems in local, national, and global perspectives.