The course provides an in-depth review of research design concepts and application of methods for clinical and nutritional investigations. The course is composed of several major topics: a) elements of research design, b) basic statistical analysis, c) critical assessment of scientific research articles, d) methods including sample selection, bias, data collection procedures, measures, analysis plan, results, discussion and interpretation of findings, e) ethical issues related to research methods. CNU608 is a required course for students in the Master of Science in Nutritional Sciences program-Clinical Nutrition concentration.