This seminar course is designed to survey major tops, concepts and issues pertinent to the field of drug and alcohol abuse and dependence. The course will consist of 14 weekly presentations by instructors followed by open discussion of the presentation and assigned readings by class members. Active participation by all members is expected. Each weekly presentation is designed to provide a general overview of the current state of knowledge (e.g., theory, methods, ethics, and review of classic and/or exemplary studies) in a given area of drug and alcohol abuse and dependence research. Discussions are intended to integrate the information across traditional and disciplinary boundaries.