This overview course is designed to introduce the student to the major methods and technologies of clinical and translational science (CTS) with an emphasis on human subjects research. Students learn these core methodologies through classroom discussions, readings, and written portfolio activities that challenge them to apply methodological concepts to their own areas of research interest. Specifically, the course teaches students how to formulate research questions and write literature reviews; apply CTS research methods, including experimental, survey, and qualitative research methodologies, to diverse areas of research by aligning appropriate methodologies to research questions of interest, and enhance interdisciplinary communication skills. It is assumed that students are engaged in research that is consistent with CTS or will become engaged in such research in the near future.