This course is designed to support clinical and translational science students in acquiring an applied understanding of the biostatistical tools and techniques commonly used in the conduct of clinical and translational science research. Through a combination of lectures, readings, demonstrations, discussions, and self-study modules, students will understand and appreciate measurement and statistical challenges that are common to clinical and translational science. Study design, selection of independent and dependent variables, and the selection and use of statistical techniques will be the focus of the course. The course activities are intended to promote the application of biostatistics to research concepts in the students' areas of interest and to foster practical knowledge that supports students' own research agendas. If the course is listed as section 001, the format of the course is a standard lecture/discussion. If the course is listed as section 002 the format of the course is a hybrid, with approximately 50% in the classroom and 50% in an on-line format.