This is an elective course for graduate students who are interested in learning nano-scale engineering and its applications in biology and medicine. The course covers a broad range of topics in nanobioengineering and nanomedicine, including synthesis, characterization, and functionalization of most common nanomaterials and nanostructures, the interactions between nanoparticles and the biological systems, current state of art in nanomaterial-based molecular imaging, drug/gene delivery, and gene editing and regulation. The topics to be discussed are of considerable importance across different research areas in bioengineering and medicine. Examples will be given to illustrate the applications of nanomaterials. The course will help develop critical reading, scientific writing, and oral presentation skills. Problem-based learning (PBL) will be incorporated throughout the course.