This course will serve as an introduction to cell and tissue level mechanobiology with focus on human physiological and disease processes. The primary focus is to introduce principles of cell-level mechanics in the context of the biology of living organisms, what we term mechanobiology. In effect, we treat biological processes and regulation as another variable(s) that must be accounted for when modeling the mechanical/physical behavior of human tissues. A large amount of the basic principles in this field of study arose as a result of the intense research in the cardiovascular field. We will draw many examples of mechanobiological principles as it relates to the circulatory system. Despite our cardiovascular focus, the basic principles can be applied to the whole range of mechanobiological research conducted in other applications (orthopedics, urological, pulmonary, etc.).