ANA 410G is a multidisciplinary discussion of neurodegenerative diseases and neurologic disorders. The course objective is to provide an in depth understanding of the basic science and clinical symptoms of selected neurologic disorders and neurodegenerative diseases, current treatment strategies and new approaches for treatment and potential cure of these devastating illnesses. Included are such topics as the 1) subcellular and molecular basis of the diseases, 2) the role of genetics in aging and neurodegeneration, 3) mechanisms of cell death, and 4) the cellular/molecular basis of neurodegenerative diseases and neurologic disorders. The format of the course will consist of a series of formal lectures and informal discussion sessions. Reference materials will be recent review articles. Graduate students taking the course will present studies from the primary medical literature in a journal club format and will also prepare a paper examining one disorder in detail. This course will be of interest to advanced students from a variety of disciplines whose interests concern brain and spinal cord disorders.