Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.
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| Abstract | :
Recent work has shown that the novel compound N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB) may selectively block nicotinic acetylcholine receptors involved in regulating dopamine release. The current experiments examined the acute effect of bPiDDB on nicotine self-administration, sucrose-maintained responding, and nicotine-induced changes in acute and sensitized locomotor activity. |
| Year of Publication | :
2006
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| Journal | :
Psychopharmacology
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| Volume | :
184
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| Issue | :
3-4
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| Number of Pages | :
426-34
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| ISSN Number | :
0033-3158
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| URL | :
https://doi.org/10.1007/s00213-005-0163-8
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| DOI | :
10.1007/s00213-005-0163-8
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| Short Title | :
Psychopharmacology (Berl)
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