Cellular oncomiR orthologue in EBV oncogenesis.
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| Abstract | :  MicroRNAs are small non-coding RNAs that regulate gene expression at multiple levels. The discovery of virally encoded miRNAs attracted immense attention towards their role in viral replication and pathogenesis. Kaposi's-sarcoma-associated herpes virus encodes miRNA that functions as an orthologue of human cellular miRNA, i.e., hsa-miR-155. Keeping the same view we extended the miRNA-homology search between the miRNAs of humans and Epstein-Barr virus. The In silico analyses shows that EBV encoded miR-BART-5 has a significant 'seed' sequence homology to hsa-miR-18 of humans. Further, the mRNA transcripts of the human genes involved in cellular growth could potentially be targeted by both viral as well as human miRNAs. The known etiological role of hsa-miR-18 as an oncomiR suggests that miR-BART-5 may function as viral oncomiR as observed in EBV-positive gastric carcinoma patients. | 
| Year of Publication | :  2011 | 
| Journal | :  Computers in biology and medicine | 
| Volume | :  41 | 
| Issue | :  10 | 
| Number of Pages | :  891-8 | 
| ISSN Number | :  0010-4825 | 
| URL | :  https://linkinghub.elsevier.com/retrieve/pii/S0010-4825(11)00155-7 | 
| DOI | :  10.1016/j.compbiomed.2011.07.007 | 
| Short Title | :  Comput Biol Med | 
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