Anti-proteinuric effect of an endothelin-1 receptor antagonist in puromycin aminonucleoside induced nephrosis in rat.
| Author | |
|---|---|
| Abstract | :
The pathogenesis of idiopathic nephrotic syndrome (INS) remains unclear although recent studies suggest endothelin 1 (ET-1) and CD80 of podocytes are involved. We investigated the potential of antagonist to ET-1 receptor type A (ETRA) as therapeutic agent through suppression of CD80 in rat model of INS. |
| Year of Publication | :
2018
|
| Journal | :
Pediatric research
|
| Date Published | :
2018
|
| ISSN Number | :
0031-3998
|
| URL | :
http://dx.doi.org/10.1038/pr.2018.11
|
| DOI | :
10.1038/pr.2018.11
|
| Short Title | :
Pediatr Res
|
| Download citation |