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Marginal correlation measures for unpaired clustered data under cluster-based informativeness

Date:
-
Location:
University of Kentucky, Statistics Department MDS 223 Refresments: 3:30-4:00 Seminar: MDS 312
Speaker(s) / Presenter(s):
Doug Lorenz Assistant Professor, University of Louisville Department of Bioinformatics and BioStatistics

In the marginal analysis of clustered data, two types of informativeness have been shown to bias standard method for marginal inference: informative cluster size, in which the number of observations in a cluster is associated with a response variable, and subcluster covariate informativeness, in which the probability that a covariate takes a certain value is associated with the response.  Monte Carlo-based within-cluster resampling estimators and cluster- and covariate-weighted analytic estimators have been suggested to adjust for both of these problems.  In this talk, we suggesting a unifying cluster-weighting paradigm for the marginal analysis of clustered data.  We then apply this paradigm to unpaired, clustered data - data which are paired at the cluster level, but unpaired within cluster - and develop marginal correlation estimators for such data.  The suggested estimators are evaluated through simulations studies, and illustrated with an application to a data from a longitudinal dental study.

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