Individual differences in novelty seeking on the playground maze predict amphetamine conditioned place preference.
Title | Individual differences in novelty seeking on the playground maze predict amphetamine conditioned place preference. |
Publication Type | Journal Article |
Year of Publication | 1999 |
Journal | Pharmacology, biochemistry, and behavior |
Volume | 63 |
Issue | 1 |
Pagination | 131-6 |
ISSN | 0091-3057 |
Abstract | Previous research has shown that a rat's level of activity in a novel environment can predict the strength of amphetamine-induced locomotor behavior and self-administration, but not amphetamine-conditioned place preference. The increase in activity observed when a rat is exposed to an inescapable novel environment may reflect escape behavior due to stress. To assess approach to novelty in a free-choice test, we examined the ability of a new test, the playground maze, to predict individual differences in response to amphetamine (1 or 3 mg/kg). Using the playground maze to categorize rats as either high or low novelty seekers, it was found that individual differences in novelty seeking did not predict amphetamine-induced changes in locomotor activity following either a single or repeated injections. However, high novelty seekers showed greater amphetamine-conditioned place preference than low novelty seekers. These results provide support for the hypothesis that novelty seeking and drug reward are neuropharmacologically related. |
URL | https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(98)00258-5 |
Short Title | Pharmacol Biochem Behav |