My research areas include behavioral pharmacology, substance abuse, and behavioral neuroscience. The general focus of my program concerns how acute doses of abused drugs alter behavioral and cognitive functioning in humans. The research combines measures of drug effects on cognitive processes with conventional assessments of abuse potential, based on subjective rewarding effects of the drug, and its ability to reinforce self-administration. The objective of these studies is to improve our understanding of how basic cognitive and behavioral mechanisms play a role in the development of substance abuse and drug addiction. Some of the general topics of study in my program include: alcohol and cocaine binges, impulsivity and ADHD as risk-factors for drug abuse, the effects of drug expectancies on behavior, and the mechanisms of placebo responses.

The studies are primarily laboratory-based experiments that involve the administration of drugs to human participants under controlled conditions. Several cognitive and behavioral functions are evaluated, including: behavioral inhibition, memory, motor coordination, and information processing. Drugs that are studied include: alcohol, cocaine, benzodiazepines, caffeine, and some current pharmacotherapies for drug abuse, such as naltrexone. The studies examine adults from various populations, including those with drug-abuse histories and those with no history of drug abuse.

My research program is funded by NIH grants from the National Institute of Alcohol Abuse and Alcoholism and the National Institute of Drug Abuse. The research is ideally suited for graduate training of students with a broad range of interests (neuroscience, clinical, cognition, etc.). Applicants to our graduate program with undergraduate research backgrounds in animal research and human cognition/learning are especially suited for graduate training in my lab.

• Fillmore, M. T., Blackburn, J. S., and Harrison, E. L. (2008). Acute disinihibiting effects of alcohol as a factor in risky driving behavior. Drug and Alcohol Dependence, 95, 97-106.
• Fillmore, M. T. (2007). Acute alcohol-induced impairment of cognitive functions: past and present findings. International Journal on Disability and Human Development, 6, 115-125.
• Fillmore, M. T., Rush, C. R., and Hays, L. (2006). Acute effects of cocaine in two models of inhibitory control: implications of non-linear dose effects. Addiction, 101, 1323-1332.
• Marczinski, C. A., *Combs, S. W., and Fillmore, M. T. (2007). Increased sensitivity to the disinhibiting effects of alcohol in binge drinkers. Psychology of Addictive Behaviors, 21, 346-354.
• Marczinski, C. A. and Fillmore, M. T. (2006). Clubgoers and their trendy cocktails: Implications of mixing caffeine into alcohol on information processing and subjective reports of intoxication. Experimental and Clinical Psychopharmacology,14, 450-458.